Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: In vivo imaging with [18F]fallypride
Identifieur interne : 000724 ( Main/Exploration ); précédent : 000723; suivant : 000725Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: In vivo imaging with [18F]fallypride
Auteurs : Marta G. Vu Ckovi [États-Unis] ; Quanzheng Li [États-Unis] ; Beth Fisher [États-Unis] ; Angelo Nacca [États-Unis] ; Richard M. Leahy [États-Unis] ; John P. Walsh [États-Unis] ; Jogesh Mukherjee [États-Unis] ; Celia Williams [États-Unis] ; Michael W. Jakowec [États-Unis] ; Giselle M. Petzinger [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-12-15.
English descriptors
Abstract
The purpose of the current study was to examine changes in dopamine D2 receptor (DA‐D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and in vivo positron emission tomography (PET) imaging employing the DA‐D2R specific ligand [18F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA‐D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise‐induced changes in the DA‐D2R in the dopamine‐depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [18F]fallypride to examine DA‐D2R changes in individuals with Parkinson's Disease (PD) undergoing high‐intensity treadmill training. © 2010 Movement Disorder Society.
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DOI: 10.1002/mds.23407
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Petzinger</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The George and Mary Lou Boone Center for Parkinson's Disease Research, Department of Neurology; University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Philips‐Fisher Center for Brain Repair and Rehabilitation, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-12-15">2010-12-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2777">2777</biblScope><biblScope unit="page" to="2784">2784</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">220129EE17A57ACA317D8DA4460DAFD947269728</idno><idno type="DOI">10.1002/mds.23407</idno><idno type="ArticleID">MDS23407</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>basal ganglia</term><term>neuroplasticity</term><term>positron emission tomography</term><term>treadmill exercise</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of the current study was to examine changes in dopamine D2 receptor (DA‐D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and in vivo positron emission tomography (PET) imaging employing the DA‐D2R specific ligand [18F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA‐D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise‐induced changes in the DA‐D2R in the dopamine‐depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [18F]fallypride to examine DA‐D2R changes in individuals with Parkinson's Disease (PD) undergoing high‐intensity treadmill training. © 2010 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Vu Ckovi, Marta G" sort="Vu Ckovi, Marta G" uniqKey="Vu Ckovi M" first="Marta G." last="Vu Ckovi">Marta G. Vu Ckovi</name></region><name sortKey="Fisher, Beth" sort="Fisher, Beth" uniqKey="Fisher B" first="Beth" last="Fisher">Beth Fisher</name><name sortKey="Jakowec, Michael W" sort="Jakowec, Michael W" uniqKey="Jakowec M" first="Michael W." last="Jakowec">Michael W. Jakowec</name><name sortKey="Jakowec, Michael W" sort="Jakowec, Michael W" uniqKey="Jakowec M" first="Michael W." last="Jakowec">Michael W. Jakowec</name><name sortKey="Leahy, Richard M" sort="Leahy, Richard M" uniqKey="Leahy R" first="Richard M." last="Leahy">Richard M. Leahy</name><name sortKey="Li, Quanzheng" sort="Li, Quanzheng" uniqKey="Li Q" first="Quanzheng" last="Li">Quanzheng Li</name><name sortKey="Mukherjee, Jogesh" sort="Mukherjee, Jogesh" uniqKey="Mukherjee J" first="Jogesh" last="Mukherjee">Jogesh Mukherjee</name><name sortKey="Nacca, Angelo" sort="Nacca, Angelo" uniqKey="Nacca A" first="Angelo" last="Nacca">Angelo Nacca</name><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name><name sortKey="Petzinger, Giselle M" sort="Petzinger, Giselle M" uniqKey="Petzinger G" first="Giselle M." last="Petzinger">Giselle M. Petzinger</name><name sortKey="Vu Ckovi, Marta G" sort="Vu Ckovi, Marta G" uniqKey="Vu Ckovi M" first="Marta G." last="Vu Ckovi">Marta G. Vu Ckovi</name><name sortKey="Walsh, John P" sort="Walsh, John P" uniqKey="Walsh J" first="John P." last="Walsh">John P. Walsh</name><name sortKey="Williams, Celia" sort="Williams, Celia" uniqKey="Williams C" first="Celia" last="Williams">Celia Williams</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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